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The evolution and changing ecology of the African hominid oral microbiome
Fellows Yates, James A, Velsko, Irina M, Aron, Franziska, Posth, Cosimo, Hofman, Courtney A, Austin, Rita M, Parker, Cody E, Mann, Allison E, Nägele, Kathrin, Arthur, Kathryn Weedman, Arthur, John W, Bauer, Catherine C, Crevecoeur, Isabelle, Cupillard, Christophe, Curtis, Matthew C, Dalén, Love, Díaz-Zorita Bonilla, Marta, Díez Fernández-Lomana, J Carlos, Drucker, Dorothée G, Escribano Escrivá, Elena, Francken, Michael, Gibbon, Victoria E, González Morales, Manuel R, Grande Mateu, Ana, Harvati, Katerina, Henry, Amanda G, Humphrey, Louise, Menéndez, Mario, Mihailović, Dušan, Peresani, Marco, Rodríguez Moroder, Sofía, Roksandic, Mirjana, Rougier, Hélène, Sázelová, Sandra, Stock, Jay T, Straus, Lawrence Guy, Svoboda, Jiří, Teßmann, Barbara, Walker, Michael J, Power, Robert C, Lewis, Cecil M, Sankaranarayanan, Krithivasan, Guschanski, Katerina, Wrangham, Richard W, Dewhirst, Floyd E, Salazar-García, Domingo C, Krause, Johannes, Herbig, Alexander, Warinner, Christina
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2021-05-18
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dental calculus
microbiome
Neanderthal
primate
salivary amylase
microbiome
Neanderthal
primate
salivary amylase
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The microbiome plays key roles in human health, but little is known about its evolution. We investigate the evolutionary history of the African hominid oral microbiome by analyzing dental biofilms of humans and Neanderthals spanning the past 100,000 years and comparing them with those of chimpanzees, gorillas, and howler monkeys. We identify 10 core bacterial genera that have been maintained within the human lineage and play key biofilm structural roles. However, many remain understudied and unnamed. We find major taxonomic and functional differences between the oral microbiomes of Homo and chimpanzees but a high degree of similarity between Neanderthals and modern humans, including an apparent Homo-specific acquisition of starch digestion capability in oral streptococci, suggesting microbial coadaptation with host diet.
Citation
J.A. Fellows Yates, I.M. Velsko, F. Aron, C. Posth, C.A. Hofman, R.M. Austin, C.E. Parker, A.E. Mann, K. Nägele, K.W. Arthur, J.W. Arthur, C.C. Bauer, I. Crevecoeur, C. Cupillard, M.C. Curtis, L. Dalén, M. Díaz-Zorita Bonilla, J.C. Díez Fernández-Lomana, D.G. Drucker, E. Escribano Escrivá, M. Francken, V.E. Gibbon, M.R. González Morales, A. Grande Mateu, K. Harvati, A.G. Henry, L. Humphrey, M. Menéndez, D. Mihailović, M. Peresani, S. Rodríguez Moroder, M. Roksandic, H. Rougier, S. Sázelová, J.T. Stock, L.G. Straus, J. Svoboda, B. Teßmann, M.J. Walker, R.C. Power, C.M. Lewis, K. Sankaranarayanan, K. Guschanski, R.W. Wrangham, F.E. Dewhirst, D.C. Salazar-García, J. Krause, A. Herbig, C. Warinner, The evolution and changing ecology of the African hominid oral microbiome, Proc. Natl. Acad. Sci. U.S.A. 118 (20) e2021655118, https://doi.org/10.1073/pnas.2021655118 (2021).
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Copyright © 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). The attached file is the published version of the article.
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0027-8424
EISSN
1091-6490